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A rule-based language
for modeling protein interaction networks

# Kappa allows the expression of protein-protein interactions
# to build executable models of protein networks
'EGFR phosphorylated on residue Y1148 binds the PTB domain of Shc' \
EGFR(Y1148~p), Shc(PTB) -> EGFR(Y1148~p!1), Shc(PTB!1)

  • November, 2012
    KaSim 3.1 has been released. This is a bug fix release.
  • July, 2012
    KaSim 3.0 has been released.
  • January, 2012
    KaSim 2.0 has been released.
  • November, 2011
    The best model prize at the iGEM 2011 European Jamboree was won by the Edinburgh team using Kappa.
  • October, 2011
    The old RuleBase.org was shut down on October 31st and replaced by a new streamlined model hosting service.
  • June, 2011
    KaSim v 1.07 was released for testing with an updated manual.
  • November, 2010
    The best model special prize for this year's IGEM went to the Edinburgh team who used the Kappa language and some exciting space-related extensions!

  • October, 2010
    Jean released KaSim, a new, rewritten version of the Ocaml simulator.
  • June, 2010
    Cellucidate.com has been renamed to RuleBase.org to reflect its transition from a commercial tool, supported by proprietary technologies, to an academic tool, supported by open source technologies.
  • May, 2010
    KappaLanguage.org launches!